Monthly Archives: October 2016

November 2016

By Lynn Dicurie

Life Extension Magazine

Nature often provides some of the most powerful tools for maintaining human health. For centuries traditional medicine has celebrated the bright red pomegranate for its healing properties. Modern science now backs up these ancient claims with compelling evidence about how the compounds inside this fruit interact with human cells. Researchers are discovering that the seeds and juice contain unique chemicals that actively promote cellular health and defend the body against various diseases.

Among the most exciting areas of current medical research is the relationship between pomegranate extract and cancer prevention. Scientists have identified specific compounds in the fruit that appear to interrupt the biological processes that allow tumors to grow and spread. These compounds work together to create a hostile environment for abnormal cells while supporting the healthy tissues surrounding them.

This post explores the fascinating science behind pomegranate and its potential role in cancer protection. We will examine how its unique chemical makeup affects specific types of tumors including prostate colon and breast cancers. You will also learn about the seven distinct biological mechanisms this fruit uses to help your body defend itself against disease.

How Pomegranate Slows Prostate Cancer Progression?

Prostate cancer remains a significant health concern for men worldwide. Medical researchers have spent decades looking for natural ways to slow its progression and support conventional treatments. Pomegranate has emerged as a highly promising candidate in this field of study. Clinical trials have shown that men who consume pomegranate extract experience a significant increase in their prostate specific antigen doubling time. A longer doubling time indicates that the cancer is growing much more slowly.

The secret lies in the unique polyphenols found abundantly in the fruit. These plant chemicals specifically target the pathways that prostate tumor cells use to multiply. By interfering with these cellular signals the active compounds force the abnormal cells to stop dividing. Furthermore they help prevent the tumor from developing the new blood vessels it needs to survive and expand.

Regular consumption of the juice or extract also appears to reduce overall inflammation in the prostate gland. Since chronic swelling often creates an environment where abnormal cells can thrive reducing this irritation is a critical step in slowing disease progression. Patients using this natural supplement alongside their primary medical care often report better overall outcomes and improved quality of life.

Is Pomegranate Well Absorbed by the Body?

A common problem with many natural supplements is poor absorption during digestion. You might consume a highly beneficial plant compound only to have your digestive system break it down before it can reach your bloodstream. Fortunately the human body processes pomegranate in a highly efficient and unique way.

When you consume the fruit or its juice the complex polyphenols travel to your lower intestine. There your natural gut bacteria feast on these compounds and convert them into smaller molecules called urolithins. These newly formed molecules easily pass through the intestinal wall and enter your blood.

Once in the bloodstream urolithins travel throughout the entire body to deliver their protective benefits. They are highly stable and can remain active in your system for a significant amount of time. This efficient conversion and absorption process explains why even moderate amounts of the extract can produce measurable positive effects in clinical trials.

Protective Actions Against Colon and Breast Cancer

The protective benefits of this fruit extend far beyond the prostate gland. Researchers have uncovered remarkable evidence regarding its effects on both colon and breast tissues. In the digestive tract the high concentration of antioxidants helps protect the delicate lining of the colon from cellular damage.

Colon cancer often begins with chronic irritation and oxidative stress in the digestive tract. The active compounds in pomegranate neutralize harmful free radicals before they can damage healthy DNA. Additionally the urolithins created during digestion accumulate in the colon tissue where they actively suppress the formation of precancerous polyps. They help maintain a healthy balance of gut bacteria which is essential for long term digestive health.

For breast cancer prevention the fruit offers a different but equally impressive mechanism. Certain types of breast tumors rely on the hormone estrogen to grow and multiply. Pomegranate contains natural substances that gently modulate estrogen receptors in the body. These compounds can block the stronger cancer promoting estrogens from attaching to breast tissue cells. By occupying these receptor sites the plant compounds help starve the tumor of the hormonal fuel it needs to expand.

Seven Ways Pomegranate Attacks Cancer

Scientists have identified seven distinct ways that the compounds in this fruit actively fight against tumor development and growth.

1. Inducing Apoptosis
   Healthy cells have a built in self destruct mechanism that activates when they become damaged. Cancer cells somehow turn off this programming allowing them to live forever. Pomegranate compounds force these abnormal cells to turn their self destruct sequence back on.
2. Inhibiting Cell Proliferation
   Tumors grow because abnormal cells divide rapidly and uncontrollably. The active ingredients in the extract interfere with the reproductive cycle of these cells stopping them from multiplying.
3. Blocking Angiogenesis
   To grow beyond a microscopic size a tumor must trick the body into building new blood vessels to feed it. Pomegranate polyphenols disrupt the chemical signals that trigger this new blood vessel formation.
4. Reducing Inflammation
   Chronic swelling provides a perfect breeding ground for disease. The powerful antioxidants in the fruit drastically reduce inflammatory markers throughout the body creating a hostile environment for tumors.
5. Preventing Metastasis
   One of the most dangerous aspects of cancer is its ability to spread to other organs. The extract helps strengthen the barriers between tissues and reduces the enzymes that tumors use to break through into the bloodstream.
6. Protecting DNA
   Oxidative stress can damage healthy DNA and trigger mutations that lead to disease. The high concentration of free radical scavengers in the fruit shields your cellular blueprints from this type of damage.
7. Modulating Hormones
   As seen with breast and prostate tissues the plant chemicals can regulate hormone production and receptor activity. This prevents hormone sensitive tumors from accessing the chemical signals they need to grow.

Adding Protective Foods to Your Daily Routine

The extensive research surrounding this vibrant red fruit paints a clear picture of its medical potential. From slowing prostate tumor growth to protecting breast and colon tissues pomegranate offers a multifaceted approach to cellular defense. Its unique ability to be easily absorbed and transformed by our gut bacteria ensures that its protective compounds reach the areas of the body that need them most.

While no single food can completely prevent or cure disease a diet rich in powerful plant compounds builds a strong foundation for long term health. Adding a high quality extract or drinking the pure juice daily is a simple step you can take to support your cellular health. Talk to your healthcare provider about how you can safely incorporate this incredible fruit into your wellness plan.

References

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Scientists have determined that fighting the biological process of aging at the cellular level will pay off big, with revolutionary new treatments.

In 400 BC, Hippocrates made an observation he thought was a secret to longevity. Obesity appeared to lead to an early death, so he thought restraint was the key to living longer. It would be over 2000 years before science would confirm his suspicions. In the 20th century, scientists made the link between calorie restriction and longer life. Yet, for most people, the thought of growing old conjures up images of debilitating disease and undue suffering in the final years. Today however, scientists are taking a new approach to the problem. They have determined that targeting the biological process of aging at the cellular level will pay off big with revolutionary new treatments.

Understanding the Biology of Aging to Fight Disease
More scientists like Dr. Lindsay Wu, organiser of the recent inaugural Australian Biology of Ageing Conference, are studying the biology of aging as a possible way to fight age-related diseases. There are similar cellular aging processes in diseases like Alzheimer’s, cardiovascular disease, diabetes, and cancer. If they are successful in treating the process of aging at the cellular level, this research field could have a huge impact on the future treatment of diseases.

Steady progress on several fronts gives researchers optimism. Scientists at UNSW’s Laboratory for Ageing Research and at Harvard Medical School have isolated a compound in red wine that prolongs life in test animals. In New York, a drug trial tested on humans is for the first time targeting aging instead of a disease. Recently, scientists were able to target and kill aging cells in lab mice with remarkable results – the mice extended their lives over 30%.

The compound resveratrol, found in red wine was discovered by researcher David Sinclair in 2003. Sinclair’s research demonstrated that doses of resveratrol made SIRT1 molecules more active in small organisms, and extended their lifespan. His work went on to be published in the journal Science and is opening the way to future anti-aging drugs. Resveratrol is already commercially available as a supplement. Though not proven in humans yet, because of our long life spans, researcher David Sinclair swears it works and regularly uses the supplement.

Killing Aged Senescent Cells & Fixing Damaged DNA
Researchers are looking at ways to target age-damaged cells, called senescent cells. Normally, our immune system would destroy these cells, but as we grow older it slowly loses this function. As a result, our bodies accumulate senescent cells which also go on to damage adjacent healthy cells. This leads to a cascade of aging in our bodies resulting in chronic inflammation, a key signature of age-related diseases.

In a recently published report in the journal Nature, Doctor Darren Baker and his team at the Mayo Clinic College of Medicine has a new strategy for dealing with aging cells. They are already developing compounds that can seek out and kill senescent cells in humans. He stressed the goal is to improve our health as we grow older, as well as extending our life spans.

A promising area of research is focused on fixing and maintaining our DNA. The goal here is to keep ourselves in a more youthful state by slowing down aging. Researchers have found a molecule called SIRT1, which has a significant role of keeping our DNA structure in a normal state. But as we grow older, this structure becomes loose and can alter the genetic code, which in turn can cause many diseases. The scientists are working on theories on how to energize this SIRT1 molecule to help keep our DNA tightly wound.

Healthy Eating & Exercise – the Key to Longevity
Calorie restriction and regular exercise both have proven to stimulate the sirtuins (SIRT1 to 4) and are responsible for the association of longevity in humans. Scientists have evidence that calorie restrictive diets are associated with longer lifespans. A low protein / high carb diet has been linked to living longer and healthier. This is the traditional diet of people on the Island of Okinawa Japan, known for the high percentage of centenarians.

Researchers are confident average lifespans between 100 to 150 years are achievable. However, Baker is more realistic, saying that everyone can take steps right now to live healthy and long lives. It’s all about the levels of damaged senescent cells in the body. There are fewer of these aged cells in people who exercise regularly and eat a healthy diet. These are easy to achieve lifestyle changes. If you look after yourself, you may live long enough to take advantage of future anti-aging treatments.

SOURCE: WorldHealth.net

The pharmaceutical industry continues to play a major role in hormone replacement therapy, often driven by profit and market demand. While there are many hormone therapy products available today, marketing can sometimes overshadow scientific evidence and common sense.

Research has consistently shown that many synthetic hormone products come with risks and limitations. These hormones are intentionally designed to differ from natural human hormones so they can be patented and commercially marketed.

However, these differences can lead to real health risks, which is why regulatory agencies require warning labels on many synthetic hormone therapies.

The Human Body and Hormonal Balance

The human body is an incredibly complex system made up of trillions of cells working together in harmony. These cells rely on precise communication and balance to function properly and maintain overall health.

Hormones play a central role in this system. They act as messengers that regulate essential processes throughout the body.

When hormone production is disrupted, even slightly, it can disturb this balance and lead to a wide range of symptoms.

This is commonly seen during stages such as perimenopause, menopause, and andropause. When key hormones like testosterone and estradiol decline, the body begins to experience noticeable changes.

Symptoms of hormonal imbalance may include hot flashes, migraines, mood swings, anxiety, depression, sleep disturbances, low libido, erectile dysfunction, fatigue, lack of motivation, and difficulty concentrating.

Why Synthetic Hormones May Not Be the Best Choice?

From a scientific and physiological perspective, using synthetic hormones to correct hormonal imbalance may not be the most effective approach.

Synthetic hormones are not identical to the hormones produced by the human body. Because of this, they may not bind properly to hormone receptors or support the natural balance of the endocrine system.

While they may temporarily relieve certain symptoms, they do not address the underlying imbalance in a way that aligns with the body’s natural processes.

This mismatch can increase the risk of side effects and long term health complications, making it a less reliable option for many individuals.

Are Bioidentical Hormones a Better Option?

Bioidentical hormones are designed to match the structure of the hormones naturally produced by the body. This allows them to interact more effectively with cells and support normal biological functions.

Bioidentical hormones are designed to match the structure of the hormones naturally produced by the body. This allows them to interact more effectively with cells and support normal biological functions.

Research suggests that these hormones perform the same roles as natural hormones, helping to maintain a stable and healthy internal environment.

What Makes Hormone Therapy Effective?

The effectiveness of hormone therapy depends on how closely it aligns with the body’s natural processes.

A scientifically sound approach focuses on delivering hormones in a way that mimics the body’s own production. This includes providing consistent hormone levels and maintaining the correct balance between different hormones.

The body requires precise hormone ratios to function properly. Too much or too little of any hormone can disrupt this balance and lead to unwanted symptoms.

For example, excess estrogen in women may cause bloating, breast tenderness, sleep disturbances, and other health concerns. Similarly, low testosterone levels in men can lead to fatigue, reduced libido, and hormonal imbalance that affects overall health.

Why Treating Only One Hormone Can Create Problems?

Hormones do not work in isolation. They function as part of a complex system where each hormone influences others.

Treating a hormone deficiency by replacing only one hormone often fails to restore true balance. Instead, it can create new imbalances that lead to additional symptoms and health risks.

For women, supplementing only estrogen can result in estrogen dominance, which may cause moderate to severe symptoms and increase the risk of certain health conditions.

For men, focusing only on testosterone without addressing its relationship with other hormones can lead to elevated estrogen levels. This imbalance may result in fatigue, mood changes, reduced sexual function, and other concerns.

A Science Based Approach to Hormone Health

A balanced and science driven approach to hormone therapy focuses on restoring the body’s natural equilibrium.

This involves using hormones that the body can recognize and utilize effectively, while also ensuring that all key hormones are maintained in proper balance.

By addressing the root cause of hormonal imbalance rather than just treating symptoms, individuals can achieve better long term health outcomes and improved quality of life.

SOURCE: SottoPelle

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3 Moskowitz D. A comprehensive review of the safety and efficacy of bioidentical hormones for the management of menopause and related health risks. Altern Med Rev. 2006 Sep;11(3):208-23. http://www.ncbi.nlm.nih.gov/pubmed/17217322/
4 Nelles JL, Wen-Yang Hu, Prins GS, Estrogen action and prostate cancer. Expert Rev Endocrinol Metab. 2011 May; 6(3): 437–451.

Hormone loss due to aging is an unfortunate reality everyone must face at some point. For most men and women, hormone production begins to slow in their 40s and continues to diminish until menopause or andropause. That’s when blood levels of estradiol (in women) and testosterone (in both sexes) drop dramatically. The physical, emotional and mental consequences that accompany this hormone deficiency can be devastating and life altering.

One of the most frequent complaints heard by doctors is the loss of sex drive. Other related symptoms often coincide. These can include erectile dysfunction, difficulty getting aroused, decreased pleasure, problems achieving orgasm, pain during sex and others. Sadly, many marriages and relationships suffer in the absence of sexual intimacy.

Symptom Relief Isn’t Enough
Although there’s a big market for erectile dysfunction pills, testosterone gels, vaginal creams and other products, these remedies are not meant to restore your body to balance. They primarily offer relief from a few symptoms. These medications may help you regain the ability to achieve intimacy, but most of the treatments are limited, imperfect and not sustainable for the long run. Some even cause dangerous side-effects.

Restoring Hormonal Balance Is the Key to Revitalizing Your Sexy Side
Every hormone has important tasks to perform. For most of your life, your hormones have operated synergistically as a team to provide you with health and well-being. When one or more are missing, your body’s systems, organs, glands and cells are thrown off kilter. That’s why your sex life has disappeared, you can’t sleep or think clearly and you’ve gained weight and lost motivation.

The good news is you don’t have to live like this. Rather than putting a band aid on it, properly administered bioidentical hormone pellet therapy can help you restore hormonal balance and feel alive again. This method has been around and researched for more than 75 years. Pellet implants have proven to be the most effective and safest method of hormone replacement available when properly administered. It is the only hormone replacement method that works with the body around the clock, for months at a time, to help achieve the hormonal balance that relieves symptoms and restores well-being.

According to thousands of men and women who are already using this treatment, it has helped them regain their lives, recapture sexual intimacy and even save their marriages and relationships. That’s a strong testament as to why hormonal balance (and not just symptom relief) should be the priority for every hormone replacement therapy.

Don’t suffer a minute longer. Call us to schedule a consultation.  We’d be happy to help you regain what you thought was lost forever—not just your love life, but your well-being and joy of living.