BHRT for Parkinson’s Disease and Traumatic Brain Injury

BHRT for Parkinson’s Disease and Traumatic Brain Injury

BHRT or Bio-identical Hormone Replacement Therapy helps restore hormones such as testosterone, estrogen, and progesterone to their required levels. The hormones are taken from plant sources to produce molecules which are identical to the hormones our body naturally makes. BHRT is a safe and a reliable method and patients who undergo the treatment have reported feeling younger, more energetic and having decreased symptoms of menopause and andropause (male menopause) symptoms. The therapy is customized to an individuals requirements and is highly effective in both men and women. There are many benefits of BHRT which include:

  • Improved immune system
  • Increased sex drive
  • Balanced weight
  • Improved skin condition
  • Lower depression
  • A new study also suggests that it helps in Parkinson disease and traumatic brain injury

Parkinsons disease and BHRT:Parkinsons disease (PD) causes the failure and death of critical nerve cells in the brain that are called neurons. PD usually strikes the neurons in the brain area called the substantia nigra that produces dopamine. Dopamine is responsible for communicating with the part of the brain that controls movement and coordination in a human body. As PD advances, dopamine production decreases which leaves a person unable to control his movements like a normal human being. This also inhibits his ability to exercise or maintain his fitness.However, with BHRT, PD patients have reported improvement in the following areas:

  • Reduced progression of PD symptoms
  • Reduced need for medicines
  • An improvement in fitness
  • An improvement in coordination
  • Better mobility
  • Reduction in tremors

These improvements are possible with BHRT as BHRT is able to increase the production of dopamine and decrease inflammation in the female brain and testosterone in the main brain. BHRT keeps hormones in balance and revives quality of life of PD patients. Balance of hormones means a steady flow of hormones in the blood stream that helps keep PD negative symptoms in check.Also, BHRT is customized as per the needs of the individual patient. This customization to the precise needs of the patients body is the key to the success of pellet therapy. SottoPelle’s patent pending dosing method BioCalc allows for the treating physician to dose the pellet therapy to exactly what that patients body requires to regain balance.

Traumatic brain injury and BHRT:Research suggests that traumatic brain injury affects around 1.7 million Americans per year and it can cause cognitive, emotional as well as physical deficits. Most therapies do not provide significant improvements or recovery and the chronic symptoms continue to be a part of life of the patients forever. It has been found that brain trauma causes deficiencies in some types of hormones. When this deficiency in hormones is restored, a significant improvement is seen in patients that suffer from traumatic brain injury.BHRT are plant-based hormones that match the exact molecular structure, as well as functionality of the human hormones. Hence, BHRT bind and communicate properly to the human body receptors and hence, extend vital support to organs, tissues and cells in the human body. If prescribed properly, BHRT can benefit traumatic brain injury as well as menopause, weight gain, and even osteoporosis. Again, BHRT are customized personally and have virtually no side effects. Exact dosage needs of a patient are uncovered by a series of blood tests.BHRT needs to be researched upon even more to aid people in their illnesses and improved further to provide an even better outcome for patients suffering from PD, traumatic brain injury, etc. If you need more information about this topic or SottoPelle Therapy, please call us today.

What Are The Causes of Menopause?

There are several reasons beyond age-related hormone loss that can cause a woman to enter menopause.

Causes of Menopause

Premature Ovarian Failure (POF) and Premature Menopause can occur in women under age 40. The ovaries cease to function normally and either stop or substantially slow down their production of estradiol, triggering early menopause. Women who experience this will often display a variety of symptoms normally associated with perimenopause and menopause.

Surgical Menopause can take place anytime in a woman’s life. It involves the surgical removal of the ovaries (oophorectomy) and/or uterus (hysterectomy), causing an abrupt halt in the manufacture of estradiol, testosterone and progesterone – steroid hormones created in the ovaries. Many women are taken by surprise when this hormone loss prompts the immediate onset of a variety of uncomfortable symptoms such as hot flashes, night sweats and others.

Chemotherapy and radiation therapy for cancer can bring about menopause accompanied by a variety of symptoms. This can happen either during or shortly after treatment and often triggers the cessation of both menstruation and fertility. These circumstances may be temporary in the case of chemotherapy, but not always.

Aging-related Hormone Decline is the most common cause of menopause. It occurs in the majority of women somewhere between the ages of 40 and 60. The average age for menopause in American women is 51. What many women think of as menopause is actually the intermediate stage beforehand, called perimenopause. This stage lasts about four or five years. It is often a time of hormonal and emotional upheaval as hormone levels fluctuate wildly and cause an onslaught of disruptive symptoms. Menopause finally arrives when the ovaries stop producing estradiol altogether and create only trace amounts of progesterone and testosterone.

Note that some symptoms can be due to causes other than hormonal imbalance or menopause. In the cases of POF and premature menopause, the symptoms appear gradually, starting at an early age. If you do have symptoms, you will want to be sure you are otherwise in good health. You need to be evaluated by a physician who takes into account your medical history, menstrual periods, medications and other related issues. Request a physical exam, a mammogram and Pap test, in addition to blood labs measuring hormone levels.

4 Common Menopause Myths

So many women come to me not fully understanding what menopause is or why they’re feeling so out of sorts. Most grew up in a time when menopause simply wasn’t talked about. Their mothers called it “the change” but never explained what was changing. I think that’s why there is so much misinformation and mythology attached to menopause.

It’s very important to me as a hormone replacement physician to help educate my patients and dispel some of the most common menopause myths.

4 Common Menopause Myths

1) Menopause ends when your hot flashes disappear

2) Estrogen is only used for hot flash relief and nothing else.

3) All estrogens are the same

4) Testosterone isn’t necessary for women

The Reality:

1) Just because you no longer experience a hot flash doesn’t mean menopause is over. Menopause is defined by deficiencies in your primary steroid hormones—estradiol (your most important estrogen) and testosterone. Because of this, the physical and emotional changes of menopause can continue until you die. That is unless you return these hormones to normal, beneficial levels using a hormone replacement method that gives the body what it needs for renewed hormonal balance.

2) Estrogen, estradiol in particular, has many important functions besides relieving symptoms like hot flashes. Estrogen receptors exist in cells throughout the body. Besides providing the basis for female reproduction and sexual development, estrogen has a significant effect on bone and bone structure. It supports liver function and provides cardiovascular protection in addition to neuroprotection in the brain. Estrogen also plays a positive role in a woman’s mental health.

3) All estrogens are not the same. The human body makes three different estrogens—estriol, estrone and estradiol. Estradiol is a woman’s most important estrogen and delivers the greatest health benefits. It is the only estrogen that penetrates the blood brain barrier. Synthetic estrogens and horse estrogen (derived from the urines of pregnant mares) have completely different structures and don’t provide the health advantages that bioidentical estradiol does.

4) Research continues to show the importance of physiologic testosterone levels in women. Premenopausal women make 300 milligrams of testosterone a day. With the onset of menopause, testosterone production slows to a trickle. In fact, this hormone is vital to hormonal balance, brain function (especially short-term memory), the normal performance of the muscle system and in bone making. The lack of testosterone creates a metabolic imbalance which causes a rise in insulin resulting in belly fat, elevated lipids and weight gain.


The Quintessential Anti-Aging Essential

Engage in daily exercise, even at a modest level, to slash your risks of premature death.

A mountain of evidence documents that physical inactivity raises a person’s risk of premature death, as well as increases the risks of diseases such as heart disease and cancer.  Ulf Ekelund, from, the University of Cambridge (United Kingdom), and colleagues assessed the link between physical inactivity and premature death.  The team analyzed data collected on 334,161 men and women across Europe, enrolled in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. Over an average of 12 years, the researchers measured height, weight and waist circumference, and used self-assessment to measure levels of physical activity. Data analysis revealed that the greatest reduction in risk of premature death occurred in the comparison between inactive and moderately inactive groups. The investigators estimated that daily exercise burning between 90 and 110 kcal (‘calories’) – roughly equivalent to a 20-minute brisk walk – would take an individual from the inactive to moderately inactive group, and reduce their risk of premature death by between 16-30%. The impact was greatest amongst normal weight individuals, but even those with higher BMI saw a benefit. In further calculations, ther team reveals that 337,000 of the 9.2 million deaths amongst European men and women may be attributed to obesity (classed as a BMI greater than 30) – with double this number of deaths (676,000) attributable to physical inactivity.  The study authors report that: “The greatest reductions in mortality risk were observed between the 2 lowest activity groups across levels of general and abdominal adiposity, which suggests that efforts to encourage even small increases in activity in inactive individuals may be beneficial to public health.”

Should Women Consider Taking Testosterone?

By Linda Dyett

Use is currently limited, but a number of studies show considerable proven and potential benefits

Naomi, 55, a human resources executive in Guttenberg, N.J., had a hysterectomy in her 30s and suffered from hormone depletion for years afterward. “I spent a decade and a half in a fog,” she says. “I lost all my sexuality and felt numb at the mere thought of sex. I cried at the drop of a hat and had sweating, pain, swelling and mood swings. My muscles were so weak that I broke my ankle — me, a high-heel wearer.”

Fearing the potential side effects, Naomi had resisted estrogen therapy. But then five years ago, when she’d reached a low point and was ready to leave the job she loves, her gynecologist, Dr. Nancy Lebowitz, a clinical instructor at New York’s Cornell Medical Center, started her on another form of hormone replacement, which she has remained on ever since. “Within a week,” Naomi says, “the light came back in my life. I felt like a woman of 25. It was amazing. I no longer have those weepy moments or night sweats. I know I sound like an addict, but I’m really not.”

(MORE: What to Do About Loss of Libido)

Greer, also 55, a pediatric dietician in Dayton, Ohio, received a diagnosis of metastatic breast cancer at age 34. She recovered after chemotherapy, radiation and bone marrow transplants, but was left feeling chronically tired, moody and forgetful, with little interest in sex. Five years ago, Dr. Rebecca Glaser, a local breast surgeon, started her on a treatment, which she continues today, that has improved her mood, memory and libido. “I feel even-keeled and normal, and my energy level is fantastic,” she says. “After so many difficult years, nothing could be better than that.”

The therapy in both cases? Testosterone, widely and misleadingly understood to be the “male” hormone. Men produce 10 times more testosterone than women, but in their early reproductive years women have 10 times more testosterone than estrogen coursing through their bodies. And many experts now believe that it’s the loss of testosterone, and not estrogen, that causes women in midlife to tend to gain weight, feel fatigue and lose mental focus, bone density and muscle tone — as well as their libido. “Testosterone is our most abundant biologically active hormone,” says Glaser, an assistant clinical professor of surgery at Wright State University’s Boonshoft School of Medicine and a leading researcher and advocate of testosterone therapy for women. “Adequate levels of testosterone are necessary for physical and mental health in both sexes.”

Benefits for Women

“Women, before, during and past menopause, and sometimes as early as in their mid-30s, invariably have low testosterone levels,” Glaser says. Not all of them will experience its wide variety of symptoms, like low libido, hot flashes, fatigue, mental fogginess and weight gain. For those who do, and who seek to avoid taking synthetic oral hormones (shown by National Institutes of Health findings to pose an increased risk for breast cancer, heart attack, stroke, blood clots and dementia), bioidentical testosterone (whose molecular structure is the same as natural testosterone) has been shown to be safe and effective.

Some testosterone is converted by the body into estrogen — which partly explains why it is useful in treating menopausal symptoms. For those at high risk for breast cancer, or who have had it, that conversion can be prevented by combining testosterone with anastrozole — an aromatase inhibitor that prevents conversion to estrogen. Nonetheless, testosterone has been shown to beneficial for patients with breast cancer. Preliminary data presented at the American Society of Clinical Oncology have shown that, in combination with anastrozole, testosterone was effective in treating symptoms of hormone deficiency in breast cancer survivors, without an increased risk of blood clots, strokes or other side effects of the more widely used oral estrogen-receptor modulators tamoxifen and raloxifene.

(MORE: Is Menopausal Hormone Therapy Right for You?)

Other benefits cited for testosterone therapy include:

Relieving symptoms of menopause, like hot flashes, vaginal dryness, incontinence and urinary urgency.
Enhancing mental clarity and focus. Researchers at Utrecht University in Holland recently found that testosterone appears to encourage “rational decision-making, social scrutiny and cleverness.”
Reducing anxiety, balancing mood and relieving depression combined with fatigue. Dr. Stephen Center, a family practitioner in San Diego who has treated women with testosterone for 20 years, says the regimen consistently delivers “improvement in self-confidence, initiative and drive.”
Increasing bone density, decreasing body fat and cellulite, and increasing lean muscle mass. “Testosterone is the best remedy available for eliminating midlife upper-arm batwings,” says Dr. George Yu, a urologic surgeon and aging specialist at Aegis Medical and Research Associates in Annapolis, Md.
Offering protection against cardiovascular events, by increasing blood flow and dilating blood vessels, and against Type 2 diabetes, by decreasing insulin resistance.

Countering the Myths

Men and women in the United States have used testosterone therapy since the late 1930s, in many instances for more than 40 years — with only rare adverse results. Yet many patients, and doctors, are unaware of testosterone therapy for women. The number of women in the United States currently on testosterone therapy is estimated to be in the tens of thousands — miniscule compared with the millions prescribed oral estrogen-progestin regimens, like Premarin and Provera.

With a growing recognition of testosterone’s benefits for women, those numbers may increase, but it may still be a while before the therapy reaches the mainstream. Advocates say that the very idea requires a rethinking of long-held notions about hormones. And many women have a knee-jerk suspicion that any hormone treatment can increase their risk of breast cancer. However, clinical studies show that testosterone not only does not increase a woman’s risk of breast cancer, it may play a key role in warding off the disease.

Some women believe, also incorrectly, that testosterone therapy will produce “masculinizing” traits, like hoarseness and aggression. While the hormone may cause inappropriate hair growth and acne in some women, those side effects can be remedied by lowering the dose.

Testosterone therapy has been approved for a variety of conditions in women as well as men in Britain and Australia. But while the U.S. Food and Drug Administration has approved of testosterone for use in men whose natural levels are low, the agency has not sanctioned it for women, for any reason. In 2005, the FDA denied approval for a women’s testosterone patch, citing concerns about long-term safety. Similar concerns have been put forth by the North American Menopause Society, although that group has also acknowledged testosterone’s efficacy in treating low libido in women.

Doctors, however, have the legal discretion to prescribe testosterone, off-label, to women, as they see fit and often do so to combat fatigue, mental fogginess and low libido. Glaser thinks this will likely remain the status quo for a while, given the prohibitive cost of conducting the long-term safety studies needed to win fuller FDA approval.

How Treatment Works

Women can take testosterone as a cream, through a patch or in the form of pellet implants, which have the highest consistency of delivery. Synthesized from yams or soybeans, and compounded of pure, bioidentical testosterone, the pellets, each slightly larger than a grain of rice, are inserted just beneath the skin in the hip in a one-minute outpatient procedure. They dissolve slowly over three to four months, releasing small amounts of testosterone into the blood stream, but speeding up when needed by the body — during strenuous activities, for example — and slowing down during quiet times, a feature no other form of hormone therapy can provide.

(MORE: 7 Questions to Ask About Every New Prescription)

To determine a patient’s dosage, some doctors measure testosterone levels in the blood or saliva, while others make judgments based on symptoms. The problem, Glaser says, “is that testosterone is difficult to accurately measure in women. Levels vary considerably, not only throughout the month, but also during the day, making a single level unreliable.”

Side effects of the insertion procedure, which are rare, include infection, minor bleeding and the pellet “working its way out,” Glaser says. Once inserted, pellets can’t be removed. Some patients notice improvements within a day or two; others do not perceive benefits for a couple of weeks. If symptoms recur, patients can return for re-evaluation.

Pellet inserts cost about $230 to $500. Since testosterone is not FDA-approved for women, though, it is rarely covered by insurers. Advocates call this unfair, because men with sagging libidos are covered, while women seeking treatment for the same condition, to say nothing of breast cancer or heart disease, are not. Testosterone pellets have long been covered for women in Britain.

Since implantation is a surgical procedure, and the pellets are manufactured by a variety of pharmaceutical compounders, who may have varying safety standards, it’s important for women to consult with an experienced, board-certified physician about treatment. But while a growing number of gynecologists, family practitioners, urologists and cardiologists, among others, now treat women with pellet implants, there is as yet no national resource to direct patients to vetted doctors who provide this treatment.

Manage Parkinson’s With BHRT

Improving Neuromuscular Function with Bioidentical Hormone Replacement Therapy (BHRT).

How Parkinson’s changes the body:

When Parkinson’s disease (PD) strikes, it causes the failure and death oaf critical nerve cells in the brain, called neurons. Parkinson’s mainly affects neurons in an area of the brain called the substantia nigra. These particular neurons produce dopamine. Dopamine, in turn, communicates with the part of the brain that controls movement and coordination. As PD progresses, dopamine production decreases. This leaves a person unable to control movement in a normal way and this inhibits the ability to exercise and maintain fitness.

SottoPelle® Parkinson’s patients are enjoying a higher quality of life

• More energy & vitality
• Reduced progression of symptoms
• Better stamina & motivation to exercise
• Increased mobility and flexibility
• Improved cognitive function

Improving Parkinson’s symptoms with hormone replacement.

SottoPelle® hormone replacement – specifically testosterone replacement – aids those with Parkinson’s to exercise. It gives them the motivation, endurance and stamina to make headway in physical fitness, just as it does in those without the disease. SottoPelle® hormone therapy using estradiol pellets increases dopamine production and decreases inflammation in the female brain, as does the testosterone in the male brain.

Parkinson’s patients using SottoPelle® can experience significant improvements in their conditions. Our BHRT isn’t a cure for the disease, but our patients report it helps them manage their symptoms. This enables patients to become more functional with less medication.

Patients often tell us that our BHRT restores their quality of life. Patients prefer SottoPelle® because they don’t experience the roller-coaster ups and downs as with cream and pill hormone based therapies.

Bioidentical Hormone Therapy Provides Help for Traumatic Brain Injury

What Is Traumatic Brain Injury (TBI)?

Traumatic brain injury occurs when the head collides with something forcefully. This can happen in falls, in violent events like gunshot wounds or physical abuse, in motor vehicle accidents, in contact sports and in military combat. In fact, TBI has been called the signature injury of the wars in Iraq and Afghanistan. Recently, the NFL has received a lot of media attention due to its legal battle in the class-action concussion case.

How Many People Suffer From TBI and What Are the Symptoms?

Traumatic Brain Injury is diagnosed in approximately 1.7 million individuals annually. According to the Centers for Disease Control and Prevention, the most commonly reported traumatic brain injuries are concussions, which are considered mild.

Disorders and symptoms frequently linked with TBI include: cognitive impairments, behavioral and emotional instabilities, and physical symptoms such as headache, dizziness, vision problems, and mobility issues. Issues range from anxiety, depression, mood swings, angry outbursts, memory loss, lack of concentration, learning difficulties, and insomnia, to a higher risk for heart attack, stroke, high blood pressure, loss of libido, obesity, diabetes, loss of lean body mass, muscular weakness and others.

What Do Hormones Have to Do With TBI?

Scientists now know that TBI often damages the endocrine system, causing hormone deficiencies. Injury to the hypothalamus, located in the brain, triggers dysfunction of the pituitary gland, which, in turn, disrupts the production of adequate levels of endocrine hormones. From the list of TBI symptoms, it’s easy to see how they correlate with the symptoms of hormone deficiency. A great deal of new research is now directed at TBI and the serious, long term consequences. Some studies have shown that the hypothalamus and pituitary may never completely recover from injury.

SottoPelle® Bioidentical Hormone Replacement for Traumatic Brain Injury Patients

Most hormone replacement therapies do not provide meaningful improvements or recovery for traumatic brain injury patients. This is primarily because they cannot to deliver hormones around the clock into the blood stream. The hormonal peaks and valleys of many methods do nothing to balance hormones and are typically accompanied by recurring symptoms. That isn’t the way the body is meant to work. When hormone deficiencies are restored to beneficial levels, as they are with SottoPelle® BHRT, significant progress can be made.

Our proprietary SottoPelle® method uses low dose bioidentical hormones that exactly match human hormones. They are slowly released into the blood stream for months at a time. The pellet delivery system we utilize works in a way the body recognizes. Bioidentical hormones bind and communicate perfectly to appropriate receptors within the cells. This is vital to the proper functioning of organs, tissues and cells throughout the entire body.

When properly administered, bioidentical pellet therapy is scientifically proven to be the safest and most effective method of BHRT available. Since TBI patients will need to be on hormone replacement therapy for the rest of their lives, it only makes sense to choose a therapy that supports health rather than putting it at further risk. And because we are leaders in the field of BHRT, SottoPelle® is the perfect choice for treating TBI hormonal deficiencies.