Osteoporosis and Hormone Replacement Therapy

Osteoporosis is a bone disease occurring when the body loses too much bone, makes too little bone, or both.  Literally meaning “Porous Bone,” when viewed under a microscope, an osteoporotic bone seems to have much larger and more frequent “pores” than healthy bone.  As bones become less dense, they weaken and are more likely to break.  If you have a high risk for osteoporosis and are approaching or have already reached menopause, testosterone hormone replacement therapy is a good treatment and preventative option to consider.

HRT has traditionally been seen as the standard method of preventing osteoporotic breaks among postmenopausal women.  While we see benefits from HRT in bone density shortly after menopause, testosterone therapy should be taken long-term to have any lasting impact on bone density and health.  This will help enhance acceptability and continuation, ensuring bone protection and menopausal symptom control.

Hormone replacement therapy is effective in preventing osteoporotic fractures in women without an established disease.  Treatment of osteoporosis will reduce the risk of fracture, and it is essential to maintain bone structure as early as possible.

For more information on HRT and Bone Density or to schedule a consultation, call us today at (201)225-2525.

Hormone Imbalance and Metabolism

With warmer weather approaching, everyone is looking forward to getting outside for hiking, biking, jogging, and other outdoor activities.   If your hormones are out of balance, you may find that you don’t have the motivation or energy to exercise in order to regulate your weight.  And with a slower metabolism, you are a prime candidate to have an increase in belly fat.

There are several hormones that can inhibit a healthy metabolism, such as testosterone, estrogen, and progesterone.  Low testosterone can cause fat storage and, along with low estrogen, can increase sugar cravings.  Progesterone helps our bodies turn to sleep well and have energy.  An imbalance here can lead to overeating.

Women who use HRT typically experience fewer problems with weight gain and body fat redistribution.  Through Hormone Replacement Therapy, you may be able to rebalance your hormones and get your weight loss back on track.  In addition, our weight loss products are made of vitamins, amino acids, and lipotropic agents to give you energy, increase your metabolism, and help with fat breakdown.

Call us at 201-225-2525 to schedule a consultation and see how we can help get you back to a healthier you.

Why Do Women Need Testosterone?



When most people think of vital hormones for women, estrogen and progesterone are quick to pop up, but what about testosterone? Unbeknownst to many people, testosterone is principally produced by a woman’s ovaries and secondary by adrenal glands to aid in the development of bone strength, lean muscle mass, libido, and energy levels. Just like estrogen and progesterone, it’s vital to a woman’s well-being that her testosterone levels are properly maintained.


According to various studies conducted by Dr. Nancy Lebowitz and Dr. Rebecca Glasser, testosterone levels in women can be attributed to the following:


  • Strong evidence that testosterone not only safely treats the symptoms of breast cancer but can also prevent and limit the course of the disease
  • Protects the brain and nervous system and is beneficial in treating Parkinson’s and Alzheimer’s diseases, traumatic spinal cord injuries, seizures, MS, and PTSD
  • Improves sleep, modifies depression, irritability and anxiety, increases energy, mental activity, memory, focus and, alleviates migraine pain
  • Part of testosterone is converted into estrogen through a process called aromatization that helps with cardiovascular health and menopause symptoms


How is Testosterone administered?


At Advanced Hormone Solutions, we specialize in the plant-based SottoPelle protocol for administering Bioidentical Hormone Replacement Therapy. This method includes seamlessly inserting pellets into a small incision just beneath the upper layer of skin and covered with a simple dressing. The pellet implants are absorbed directly in to the bloodstream, slowly and consistently, on a 24 hour 365-day basis. Pellets are the preferred method of testosterone replacement therapy because other forms (synthetic) runs the risk of causing clotting issues and liver damage and can be inconsistently absorbed.


To learn more about why testosterone is vital for a woman’s health or to see if you are a candidate, please visit our consultation page and we will get back to you as soon as possible: http://advancedhormonesolutions.com/consultation-form/.


American Heart Month & BHRT



February is most notably marked as the month of love thanks to Valentine’s Day, but it’s also American Heart Month. According to the CDC, “Heart disease is the leading cause of death for men and women in the United States. Every year, 1 in 4 deaths are caused by heart disease.” The good news is with early intervention heart disease can often be prevented or reversed with the help of a balanced diet, exercise, and Bioidentical Hormone Replacement Therapy (BHRT).


As we’ve mentioned previously, hormones play a vital role in one’s heart health. According to the American Heart Association, an overall increase in heart attacks among women is seen about 10 years after menopause. The rationale behind this is that women lose the hormone Estradiol post-menopause that runs abundant prior to menopause. Estradiol is an important component to cardiovascular health because of its cholesterol regulating properties as well as supporting artery dilatation and pliability.


Hormone Replacement Therapy is a great way to prevent heart disease, but only if “natural” bioidentical hormones versus synthetic hormones are used. Another important component is the method with which these hormones are delivered. The best method is via Pellet therapy, whereby hormones (both Estradiol and Testosterone) are delivered directly to the blood stream. The combination of bioidentical hormones and our superior delivery method provides the same heart-protective benefits a woman experiences prior to the onset of menopause. Hormone replacement therapy has been found to have the biggest impact for women in their 40’s who elect to start our therapy prior to entering menopause.


To learn more about hormone replacement therapy or to start your journey in to “wellness” call us today at 201-225-2525.

Hormone Replacement Therapy and Menopause

Feb Blog Image

Menopause is a rite of passage for most women as they leave their reproductive years behind and look to the future. Unfortunately, like most hormonal and reproductive changes, menopause is not always a joyful process but instead can be emotionally, physically, and mentally taxing. Advanced Hormone Solutions aims to assist women in this transition as peacefully as possible through the use of natural bio-identical hormone replacement therapy.

When a woman goes through menopause, she essentially loses the capability to produce estradiol, testosterone, and progesterone, thus causing the endocrine system to become imbalanced. By using hormone replacement therapy, we are able to replace these hormonal losses and bring the body back into a happy equilibrium. All of these hormones work together, therefore it is vital that all three be replaced in order to achieve hormonal balance.

Progesterone is one of the most vital hormones in a woman’s body as it is used to protect a woman’s uterus in the presence of estradiol. This hormone can increase deep sleep, promote bone formation, and increase bone density. When taking natural progesterone in addition to estradiol and testosterone, women are able to combat the negative effects of estrogen dominance, moderate androgens, and regulate the body’s salt and water tolerances, therefore decreasing bloating and other dehydration.

Not all progesterone is created equal. When using progesterone, it is vital to use natural progesterone that, according to a scientific article published in 2005, does not increase the risk of breast cancer and can, in fact, have a protective effect. Alternatively, research has shown using synthetic progesterone in conjunction with hormone therapy can increase the risk of breast cancer.

For more information on hormone replacement therapy or to find out how Advanced Hormone Solutions can help ease your menopause symptoms today, call us at 201-225-2525.

Happy December!

Happy December! It’s officially the kick off to the happiest time of year with weekends booked for spreading cheer, holiday shopping, and sharing not so healthy meals with friends and family. While all of the merriment can definitely be exciting, it can also take on a life of its own. From planning the perfect holiday meal, to scratching names off that holiday gift list and navigating family politics, parts of the holiday shuffle can be stressful. This month, let Advanced Hormone Solutions help ease your worries so you can focus on the joy of the season and enter the New Year in peace!


Image Source: blog.otterbox.com

Late nights, indulging on seasonal treats, and staying awake to online shop can disrupt stable hormonal balances in the body. Hormones such as cortisol are released when your diet and sleep are altered, increasing your stress levels and wreaking havoc in your body. If the holiday rush is starting to take a toll on you, we can help.


At Advanced Hormone Solutions, we specialize in Bio-identical hormone replacement therapy. First, we run a blood test to identify areas of hormonal imbalances. Once we have our data in hand, we’ll work with you to stabilize your hormones using bio-identical hormone replacement therapy. This therapy can be as easy as applying creams, injections, gels, pills and SottoPelle® pellets. Pretty soon you’ll feel the stress melt away and be left happily ringing in the New Year!

To schedule your consultation today give us a call at 201-225-2525.

Having trouble sleeping? Hormone imbalance could be to blame.

Do you feel like you count down the seconds until bedtime all day long, only to finally lay your head on the pillow and stare at the clock? Are you awakened mid-sleep drenched in cold sweat? Are you tossing and turning from being too hot and then too cold? If you said yes to any of these questions, it might be time to talk about hormones, the hidden culprits behind sleep issues.

image source: www.prevention.com

What causes a hormone imbalance?
When your body is functioning at optimal health, hormones like estrogen, progesterone, testosterone, and thyroid are all working together. When hormones start veering off the normal course, things like sleep disturbances, mood swings, hot flashes, and weight gain tend to occur. These hormones can easily get out of sync due to many reasons out of your control, including menopause, perimenopause, and hypothyroidism. While these issues might be a fact of life, it doesn’t mean you have to suffer and never have a full night of sleep again.

What can I do to fix the imbalance?
If you feel like you’ve tried everything to no avail it might be time to consider hormone replacement therapy. Similarly to taking a multivitamin when you have a vitamin deficiency, Bio-identical hormone replacement therapy is able to supplement deficient hormone levels and replenish what your body needs in order to restore your natural chemistry. These hormones (Testosterone and Estradiol) can be administered in the form of tiny pellets placed under the upper layer of your skin.

If you’re experiencing trouble sleeping and are ready to make a change, give us a call today to schedule your consultation and start looking forward to bedtime instead of dreading it!

Why SottoPelle® Performs Better Than Other Hormone Delivery Methods

If you are considering Bio-Identical Hormone Replacement Therapy, here is Dr. Geno Tutera explaining the unique benefits of the SottoPelle protocol that he founded after many years of research.

The SottoPelle Method is an innovative breakthrough in hormone replacement therapy. By using Bio-Identical hormones your body absorbs and responds better to the therapy allowing you to flourish again! We believe that once you watch this exciting video highlighting the benefits of SottoPelle and its unique delivery methods for both women and men, you will want to know how you can get started.

How Pomegranate May Protect Against Cancer

November 2016

By Lynn Dicurie

Life Extension Magazine


Pomegranates are best known for their ability to improve arterial health.

Accumulating data have demonstrated that pomegranate has cancer protective properties as well.1-3

Some of the most promising findings on pomegranate extracts show their ability to impede progression of prostate cancer. Additional studies indicate that pomegranate may protect against breast and colon cancer as well.4,5

Dietary factors are increasingly recognized as playing a role in cancer development. More than 70% of certain malignancies—like colorectal cancer—are related to diet and lifestyle factors.6

Studies show that high fruit and vegetable consumption is associated with lower cancer incidence.6 That’s especially true when diets include large amounts of polyphenols from specific plant foods.7

The challenge is that, while adding polyphenol-rich foods to our diets is beneficial, it doesn’t always provide enough polyphenols to exert a meaningful effect on prevention.6 That’s where pomegranate extracts may play a crucial role.

Pomegranate Slows Prostate Cancer Progression

The most promising studies on pomegranate’s anti-cancer actions are on its ability to slow the progression of prostate cancer.

In prostate-cancer patients, serum PSA levels are the most commonly used marker to assess disease status. One standard for evaluating cancer progression is to measure the time it takes for PSA levels to double from a baseline value. The longer it takes for PSA to double, the slower the cancer is progressing.8

Studies show that supplementation with pomegranate juice or extracts can significantly increase the time it takes for PSA to double in men with prostate cancer. In one study, men received 8 ounces of pomegranate juice daily following surgery or radiotherapy for prostate cancer. Prior to treatment, the subjects’ PSA doubled in an average of 15 months, indicating quite rapid disease progression. But after treatment with pomegranate juice, PSA took an average of 54 months to double its value, which is a clinically and statistically significant difference.9

Another study evaluated men with recurrent prostate cancer (which is cancer that comes back after treatment such as surgery). In this study, taking pomegranate extract daily for up to 18 months increased the time it took for PSA to double from 11.9 months at baseline to 18.5 months.10

These studies offer evidence of pomegranate’s ability to slow down the progression of prostate cancer.

Pomegranate’s Targeted Effect

While most of the clinical studies on pomegranate’s anticancer benefits have been conducted in men with prostate cancer, the encouraging results can be expected to translate to other malignancies as well. In fact, numerous animal and basic lab studies have now added to our understanding of pomegranate’s promise in cancer prevention.

One of the first questions about any natural compound (or drug, for that matter) is how well it is absorbed after oral intake. It is also important to determine how much of the compound ultimately reaches its target tissues (glands, organs, etc.).

Studies show that the pomegranate components ellagitannins (which are the most abundant polyphenol found in pomegranate juice) are not only extremely well-absorbed, but also get delivered to many of the tissues where human cancers arise—especially prostate, colon, and intestinal tissues.11 This important finding was confirmed in a human study of colorectal cancer patients. When the patients supplemented with 900 mg of pomegranate extracts for 15 days prior to surgery, it resulted in significant accumulation of the extracts and their active breakdown products in colon tissue, indicating a targeted effect.2

Once they get to their target tissues, pomegranate compounds exert numerous effects that can help prevent tumors from developing and spreading. This has been demonstrated in animal studies of xenografts, which are implants of human cancer cells that are surgically engrafted into host animals. Xenograft studies now demonstrate that not only can pomegranate extracts delay the development of a tumor after it has been implanted, but they can also decrease the size and blood supply of those tumors that do develop.12-14

Supplementation with three specific compounds found in pomegranate—luteolin, ellagic acid, and punicic acid—has also been shown to inhibit the progression and spread of prostate cancer in animals injected with human tumor cells.14 In this study, pomegranate supplementation inhibited the growth of the primary tumor, and also shut down biochemical signaling pathways required for metastasis. As a result, none of the implanted tumors metastasized. This is a tremendously important finding, especially considering the terrible prognosis in humans when metastasis occurs.

Actions Against Colon and Breast Cancer

Many fast-growing tumors can be induced in small animal models by treating them with known cancer-causing chemicals. This is a technique that is commonly used in studying cancers of the colon and digestive tract.

Such cancer-inducing treatment leads to the development of early precancerous lesions known as aberrant crypt foci in colon tissue, which represent areas of abnormal cell replication and growth in the folds of tissue that line the intestine.15 If left untreated, aberrant crypt foci have a high likelihood of progressing to intestinal polyps, and then to fully-developed cancers.

But that story changes when animals are given pomegranate extracts prior to exposure to the toxic cancer-causing compound. In these scenarios, aberrant crypt foci occurred significantly less frequently in the animals supplemented with pomegranate extracts, compared to the unsupplemented animals.15-17

These studies show pomegranate’s ability to help prevent the precancerous changes that can lead to the development of tumors. Other studies go a step further, and demonstrate pomegranate’s ability to improve survival rates in animals with colon cancer.18

A study published earlier this year showed that pomegranate extracts have protective effects in chemically-induced breast cancer. When pomegranate extracts were given to rats before and after they were exposed to a chemical that caused breast cancer, the extract was found to reduce the incidence, number, and size of breast tumors. This led the researchers to conclude that pomegranate’s compounds “could be developed as a chemopreventive drug to reduce the risk of breast cancer.”19

Studies have also indicated pomegranate’s protective effect against cancer in patients with inflammatory bowel diseases. Chronic intestinal inflammation is a known precursor of intestinal malignancies, which is why inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease substantially increase the risk of such cancers.

The good news is that in studies of animals with experimentally-induced colitis, the pomegranate constituent ellagic acid has been found to inhibit the progression of colitis, and to downregulate many of the molecular signaling pathways that get switched on and promote cancer in colitis patients.20

Seven Ways Pomegranate Attacks Cancer

One reason why pomegranate extracts have demonstrated potent effects against a variety of different types of malignancies is because they mount a multitargeted attack against cancer cells. Cancer is a complicated, multifactorial disease, with no single cause and no likely single cure. Because of that, cancer prevention strategies are most effective when they simultaneously address the many underlying causes of cancer in a multitargeted fashion.

This is what makes natural compounds such as pomegranate so appealing for cancer prevention. Unlike synthetic molecules, natural compounds—especially polyphenols—are capable of a multitargeted effect because they operate within the same complicated set of rules and events that cancer itself plays by.

Studies show that pomegranate extracts and polyphenols exert seven different mechanisms of action on developing cancer cells. Let’s take a look at pomegranate’s wide ranging effects:

  • DNA damage is considered the initiating phase for cancer development. Mutations in DNA genes can arise from exposure to radiation (including ultraviolet light), to toxins, and even to byproducts of normal metabolism, such as oxidative stress. Laboratory studies demonstrate that pomegranate extracts, including punicalagin and ellagic acid, can prevent DNA damage from many different sources.21-23
  • Out-of-control proliferation of cells is the hallmark of cancer. Such proliferation occurs as a result of changes in specific genes that normally maintain regulation over the cell proliferation. When DNA regulatory genes are suppressed, endless cellular replication contributes to more rapid cancer progression. Pomegranate extracts are capable of interfering with abnormal cell-proliferation cycles, thereby impeding aberrant replication.24-27
  • Low-grade inflammation is a well-known promoter of cancer cell growth and survival.28 Pomegranate extracts and polyphenols shut down certain inflammatory signals (such as NFkappaB) and suppress the production of other pro-inflammatory molecules.12,20,29-31
  • Loss of apoptosis is another change that occurs as cells undergo malignant transformation. Normally dividing cells receive many signals to stop replicating, and in many cases, to take themselves out of the picture so that normal tissue can form. The problem is that malignant cells suppress genes that trigger apoptosis. Pomegranate extracts can restore apoptosis to cancer cells, helping to halt continued expansion and if caught early enough may prevent a tumor from forming.7,19,24,25,32,33
  • Forming new blood vessels (angiogenesis) is a necessity for burgeoning tumor cells, as they need to nourish themselves during their rapid growth spurt. Pomegranate constituents have shown the ability to inhibit angiogenesis in laboratory and animal studies.13,34
  • Invasion of local tissue and spread to distant tissue (called metastasis) heralds the advance of cancer to a much higher grade and raises the risk of death. In order to invade tissues, cancer cells produce “protein-melting” enzymes that allow them to squeeze into tiny spaces between healthy cells, while metastasis requires a host of molecular signals that allow bits of tumor to set up shop in new environments in the body. Pomegranate extracts combat both of these actions by suppressing the production of such tissue-destroying enzymes and signaling molecules, thereby helping prevent cancer cells from spreading.14,27,35
  • Growth stimulation by sex hormones is a feature of some of the most common human cancers, including those of the breast and prostate, which have cell-surface receptors for those hormones. Pomegranate extracts slow the growth of many hormone-dependent cancers.36-39



Pomegranates contain a host of protective molecules that benefit not only the plant, but those who consume it. While these constituents are best-known for reducing the risk of heart disease, they are now also being explored for their ability to help prevent cancer.

Because cancer is a multifactorial disease, any compound aimed at preventing it should have multitargeted effects. This is a virtue of the active constituents of pomegranate fruit, skin, and even leaves. Lab studies show that pomegranate extracts exert at least seven distinct beneficial effects that confer protection to cells against malignant changes, while making those that do mutate less likely to progress.

Animal studies help corroborate that pomegranate supplementation can reduce the incidence of cancers, slow their growth, and reduce the size and number of cancers that develop. Human studies indicate that pomegranate extracts are capable of slowing the progression of prostate cancer. Additional research findings indicate pomegranate’s potential benefits in breast and colon cancer as well.

Pomegranate’s multitargeted properties make it an ideal chemoprevention supplement, one that is widely available and potent in its effects. Given its cardioprotective effects, pomegranate extracts offer a well-rounded approach to protecting against some of today’s deadliest diseases.



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  4. Lee ST, Lu MH, Chien LH, et al. Suppression of urinary bladder urothelial carcinoma cell by the ethanol extract of pomegranate fruit through cell cycle arrest and apoptosis. BMC Complement Altern Med. 2013;13:364.
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  10. Kiraz Y, Neergheen-Bhujun VS, Rummun N, et al. Apoptotic effects of non-edible parts of Punica granatum on human multiple myeloma cells. Tumour Biol. 2016;37(2):1803-15.
  11. Naiki-Ito A, Chewonarin T, Tang M, et al. Ellagic acid, a component of pomegranate fruit juice, suppresses androgen-dependent prostate carcinogenesis via induction of apoptosis. Prostate. 2015;75(2):151-60.
  12. Dana N, Javanmard SH, Rafiee L. Role of peroxisome proliferator-activated receptor alpha and gamma in antiangiogenic effect of pomegranate peel extract. Iran J Basic Med Sci. 2016;19(1):106-10.
  13. Wang Y, Zhang S, Iqbal S, et al. Pomegranate extract inhibits the bone metastatic growth of human prostate cancer cells and enhances the in vivo efficacy of docetaxel chemotherapy. Prostate. 2013.
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  15. Mandal A, Bishayee A. Mechanism of Breast Cancer Preventive Action of Pomegranate: Disruption of Estrogen Receptor and Wnt/beta-Catenin Signaling Pathways. Molecules. 2015;20(12):22315-28.
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Targeting the Biological Process of Aging

Scientists have determined that fighting the biological process of aging at the cellular level will pay off big, with revolutionary new treatments. 140820_dna

In 400 BC, Hippocrates made an observation he thought was a secret to longevity. Obesity appeared to lead to an early death, so he thought restraint was the key to living longer. It would be over 2000 years before science would confirm his suspicions. In the 20th century, scientists made the link between calorie restriction and longer life. Yet, for most people, the thought of growing old conjures up images of debilitating disease and undue suffering in the final years. Today however, scientists are taking a new approach to the problem. They have determined that targeting the biological process of aging at the cellular level will pay off big with revolutionary new treatments.

Understanding the Biology of Aging to Fight Disease
More scientists like Dr. Lindsay Wu, organiser of the recent inaugural Australian Biology of Ageing Conference, are studying the biology of aging as a possible way to fight age-related diseases. There are similar cellular aging processes in diseases like Alzheimer’s, cardiovascular disease, diabetes, and cancer. If they are successful in treating the process of aging at the cellular level, this research field could have a huge impact on the future treatment of diseases.

Steady progress on several fronts gives researchers optimism. Scientists at UNSW’s Laboratory for Ageing Research and at Harvard Medical School have isolated a compound in red wine that prolongs life in test animals. In New York, a drug trial tested on humans is for the first time targeting aging instead of a disease. Recently, scientists were able to target and kill aging cells in lab mice with remarkable results – the mice extended their lives over 30%.

The compound resveratrol, found in red wine was discovered by researcher David Sinclair in 2003. Sinclair’s research demonstrated that doses of resveratrol made SIRT1 molecules more active in small organisms, and extended their lifespan. His work went on to be published in the journal Science and is opening the way to future anti-aging drugs. Resveratrol is already commercially available as a supplement. Though not proven in humans yet, because of our long life spans, researcher David Sinclair swears it works and regularly uses the supplement.

Killing Aged Senescent Cells & Fixing Damaged DNA
Researchers are looking at ways to target age-damaged cells, called senescent cells. Normally, our immune system would destroy these cells, but as we grow older it slowly loses this function. As a result, our bodies accumulate senescent cells which also go on to damage adjacent healthy cells. This leads to a cascade of aging in our bodies resulting in chronic inflammation, a key signature of age-related diseases.

In a recently published report in the journal Nature, Doctor Darren Baker and his team at the Mayo Clinic College of Medicine has a new strategy for dealing with aging cells. They are already developing compounds that can seek out and kill senescent cells in humans. He stressed the goal is to improve our health as we grow older, as well as extending our life spans.

A promising area of research is focused on fixing and maintaining our DNA. The goal here is to keep ourselves in a more youthful state by slowing down aging. Researchers have found a molecule called SIRT1, which has a significant role of keeping our DNA structure in a normal state. But as we grow older, this structure becomes loose and can alter the genetic code, which in turn can cause many diseases. The scientists are working on theories on how to energize this SIRT1 molecule to help keep our DNA tightly wound.

Healthy Eating & Exercise – the Key to Longevity
Calorie restriction and regular exercise both have proven to stimulate the sirtuins (SIRT1 to 4) and are responsible for the association of longevity in humans. Scientists have evidence that calorie restrictive diets are associated with longer lifespans. A low protein / high carb diet has been linked to living longer and healthier. This is the traditional diet of people on the Island of Okinawa Japan, known for the high percentage of centenarians.

Researchers are confident average lifespans between 100 to 150 years are achievable. However, Baker is more realistic, saying that everyone can take steps right now to live healthy and long lives. It’s all about the levels of damaged senescent cells in the body. There are fewer of these aged cells in people who exercise regularly and eat a healthy diet. These are easy to achieve lifestyle changes. If you look after yourself, you may live long enough to take advantage of future anti-aging treatments.

SOURCE: WorldHealth.net

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